Eliquis apixaban is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery. Active pathological bleeding see warnings and precautions 5. See full prescribing information for complete boxed warning. Nonvalvular afib dosing rx eliquis apixaban safety info. For patients receiving eliquis doses of 5 mg or 10 mg twice daily, when eliquis is coadministered with drugs that are combined pgp and strong cyp3a4 inhibitors. Xareltorivaroxaban or eliquisapixaban xarelto available 10mg, 15mg, and 20mg tablets. Twice weekly 2056mgm2 regimen by 30minute infusion kyprolis is administered intravenously as a 30minute infusion on two consecutive days, each week for threeweeks followed by a 12day rest period as shown in table2. If a patient is on dialysis and is above the age of 80 or weighs under 60 kg then the dose is reduced to 2. Through its action on fxa, apixaban makes blood less likely to clot. Eliquis 5 mg filmcoated tablets patient information. If you miss a dose of xarelto, take it as soon as you remember on the same day. Lovenox is indicated for the prophylaxis of ischemic complications of unstable angina and nonqwave myocardial infarction, when concurrently administered with aspirin.
This leaflet is part iii of a threepart product monograph. The risk of these events is even further increased by the use of indwelling catheters or the concomitant use of drugs affecting hemostasis. Read all of this leaflet carefully before you start taking this medicine because. Use strict aseptic techniques throughout the insertion procedure see warnings and precautions 5. In study 1, grade 3 peripheral neuropathy occurred in 8% 40503 of patients, and grade 4 in 0. Full prescribing information 1 indications and usage travatan z travoprost ophthalmic solution 0. In plato, for brilinta vs clopidogrel, noncabg platodefined major bleeding 3. Please contact pfizer canada medical information at 1 800 4636001 with any comments or inquiries. Eliquis is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery. Xareltorivaroxaban or eliquisapixaban indications and. Vte prophylaxis and treatment is critical to survival and the incidence of vte practically doubles for every decade over age 50 with a slightly higher incidence in males 1. The most common adverse reactions associated with the use of brilinta included bleeding and dyspnea.
Eliquis 5 mg filmcoated tablets patient information leaflet. Eliquis is contraindicated in patients with the following conditions. People with atrial fibrillation a type of irregular heartbeat are at an increased risk of. Accordingly, indwelling epidural or intrathecal catheters must be removed at least 5 hours prior to the first dose of eliquis. Apr 29, 2020 changing from eliquis to anticoagulant treatment containing vitamin k antagonist e.
For the 2 x 5 ml syringe package, the contents of both syringes must be injected to receive the 500 mg. Andexxa coagulation factor xa recombinant, inactivatedzhzo is a recombinant modified human factor xa fxa protein indicated for patients treated with rivaroxaban or apixaban, when reversal of anticoagulation is needed due to lifethreatening or uncontrolled bleeding. Apixaban versus warfarin in patients with atrial fibrillation. Anticoagulant table quality improvement organizations. Oral anticoagulant comparison chart remedi seniorcare. Jun 11, 2019 reduction of risk of stroke and systemic embolism in nonvalvular atrial fibrillation. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for eliquis apixaban. The primary safety endpoint was major bleeding that occurred during or within 2 days of stopping study treatment.
Medical information about eliquis apixaban from bristolmyers squib. If your doctor tells you that you have to start taking the medicine containing a vitamin k antagonist, continue to take eliquis for at least 2 days after your first dose of the medicine containing a vitamin k antagonist. If you encounter technical difficulties in viewing our product. Zoloft may be administered either continuously every day throughout the menstrual cycle or intermittently only during the luteal phase of the menstrual cycle, i.
Refer to the dexamethasone prescribing information for other information on that product. Prophylaxis of dvt following hip or knee replacement. Canadian regulations limit the scope of information we are permitted to give on prescription drugs via the internet or other means. Eliquis apixaban this product information is intended only for residents of the united states. Do not take more than one dose of eliquis at the same time to make up for a missed dose. Full prescribing information 1 indications and usage zofran is indicated for the prevention of nausea and vomiting associated with. Eliquis is a brand trade name for apixaban which is used to reduce the risk of blood clot formation. A previous version of this article incorrectly stated that apixaban eliquis has an fdaapproved indication for use in hemodialysis patients. Mirena is supplied within an inserter in a sterile package see figure 1 that must not be opened until required for insertion see description 11. Unchanged apixaban is the major drugrelated component in human plasma. Venous thromboembolism vte is manifested as deep venous thrombosis dvt and pulmonary embolism pe. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for eliquis apixaban skip to.
Revlimid lenalidomide capsules, for oral use initial u. Medication guide eliquis ell eh kwiss apixaban tablets. Inside the eliquis pack together with the package leaflet you will find a patient alert card or your doctor might give you a similar card. Download leaflet view the patient leaflet in pdf format.
Xarelto may cause serious side effects, including increased risk of blood clots if you stop taking xarelto. Bristolmyers squibbs and pfizers eliquis pharmacy times. Refer to the full prescribing information ofcoadministeredpalbociclib,abemaciclib,or ribociclibfor dose modification guidelines in the eventof toxicities, for use with concomitant medications, and other relevant safety information. For patients receiving eliquis doses of 5 mg or 10 mg twice daily when coadministered with combined pgp and strong cyp3a4 inhibitors.
Oral anticoagulant rx eliquis apixaban safety info. Avoid coadministration with combined pgp and strong cyp3a4 inhibitors. The december 2012 approval excludes atrial fibrillation as a result of a heart valve defect, as these patients were not studied in clinical trials. Eliquis apixaban medical information from bristolmyers squibb. Apixaban is a selective inhibitor of factor xa fxa, an enzyme that plays a key role in the formation of substances that cause blood clotting. Full prescribing information, including boxed warnings, and medication guide. Do not change your dose or stop taking eliquis unless your doctor tells you to. Dailymed eliquis apixaban tablet, film coated eliquis 30. A premature discontinuation of pradaxa increases the risk of thrombotic events, and b spinalepidural hematoma see full prescribing information for complete boxed warning procedures when possible, then restart promptly 2. Eliquis is indicated for the treatment of dvt and pe, and to reduce the risk of recurrent dvt and pe following initial therapy. Brilinta ticagrelor tablets for health care professionals. Major bleeding was defined as clinically overt bleeding that met 1 of the following criteria.
Apixabans package insert states that patients with atrial fibrillation may receive full dose apixaban 5 mg twice daily while on hemodialysis as long as they are under the age of 80 and weigh above 60 kg. This indication is approved under accelerated approval based on the. Bleeding risk see full prescribing information for complete boxed warning. These highlights do not include all the information needed to use bevyxxa safely and effectively. Infusion reactions and cardiopulmonary arrest 1 indications and usage 1. If eliquis must be discontinued for a reason other than pathological bleeding, consider coverage with another anticoagulant see dosage and administration 2. Highlights of prescribing information these highlights do not include all the information needed to use effientsafely and effectively. Highlights of prescribing information these highlights do not include all the information needed to use eliquis safely and effectively.
Highlightsof prescribing information kyprolis safely and. If you miss a dose of eliquis, take it as soon as you remember. Discontinuing eliquis places patients at an increased risk of. Eliquis is a medicine used to prevent venous thromboembolism blood clots in the veins in adults following a hip or knee replacement operation.
Nov 26, 2019 eliquis tablets are available for oral administration in strengths of 2. Do not use if the seal of the sterile package is broken or appears compromised. Eliquis, innapixaban european medicines agency europa. People with atrial fibrillation an irregular heart beat that is not caused by a heart valve problem nonvalvular are at an increased risk of forming a blood clot in the heart, which can travel to the brain, causing a stroke, or to other parts of the body. A vast amount of practicerelated information is available to todays healthcare practitioner. The printed package leaflet of the medicinal product must state the name and address. Full prescribing information, including boxed warnings and medication guide. Eliquis to warfarin in clinical trials in patients with nonvalvular atrial fibrillation. What is the most important information i should know about eliquis. Please consult a qualified health professional for more detailed information. It is also used in adults to treat deep vein thrombosis blood clot in a deep vein, usually in the leg and pulmonary embolism clot in a blood vessel supplying the lungs, and to prevent their. Pradaxa dabigatran etexilate mesylate capsules, for oral use.
Although clarithromycin is a combined pgp and strong cyp3a4 inhibitor, pharmacokinetic data suggest that no dose adjustment is necessary with concomitant administration with eliquis. Reduction of risk of stroke and systemic embolism in nonvalvular atrial fibrillation. Dailymed eliquis apixaban tablet, film coated eliquis. Embryofetal toxicity, hematologic toxicity, and venous and arterial. Highlights of prescribing information these highlights do not.
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